With ongoing scale-up of pre-exposure prophylaxis focused on increasing access, it is important to understand what influences adolescent girls and young women's (AGYW’s) choice of PrEP delivery platforms. The POWER implementation study in Cape Town provided PrEP to AGYW (16−25 years) from four differentiated delivery platforms: mobile clinics, government facilities, courier deliveries or community-based youth clubs. In-depth interviews were conducted with a purposive sample of AGYW who had ≥3 months of PrEP use and accessed ≥2 PrEP delivery platforms. A thematic analysis of the data explored AGYW's preferences, decision-making and habits related to PrEP access to inform market segmentation.