Researchers explored understanding of HIV serodiscordance among health care providers in eThekwini District, South Africa, and Mbarara District, Uganda. In both countries, providers who understood HIV serodiscordance were better able to describe useful HIV prevention strategies, such as antiretroviral treatment (ART), pre-exposure prophylaxis (PrEP), medical male circumcision, and couples-based HIV counselling and testing, as reported in the African Journal of AIDS Research.