The Global HIV Prevention Coalition was established in October 2017 to galvanize greater commitment to and investment in HIV prevention and to agree on a road map to meet the 2020 prevention targets. The Road Map lists four main factors that were holding back progress: gaps in political leadership, legal and policy barriers, gaps in prevention financing, and a lack of systematic implementation of combination prevention programmes at scale. The Road Map contains a 10-point plan to address these factors, which participating countries committed to implement, as well as complementary commitments by development partners and civil society, with clear targets and milestones. This first progress report mainly covers the initial implementation period, from the inaugural meeting in October 2017 to March 2018.