These technical guidelines outline the strategies for rolling out pre-exposure prophylaxis (PrEP) as an accessible HIV prevention tool. They focus on increasing the capacity of healthcare providers to prescribe and manage PrEP, ensuring that PrEP can be accessed in appropriate settings and generating demand for PrEP across populations with an emphasis on online and virtual strategies. The implementation of these guidelines will enable India to integrate PrEP with a variety of health services and accelerate progress in reducing HIV incidence.