This technical brief seeks to establish the importance of implementing psychosocial interventions to optimize HIV outcomes and support mental health for adolescents and young people living with HIV; to provide evidence on how this can and has been done; and to chart a way forward for the integration of mental health and HIV services for this population. The brief also identifies emerging best practices and strategic actions to ensure that sustained investments in the health and well-being of young people can be realized at a pivotal global moment.