These guidelines support delivery of quality, nonjudgmental, people-centred HIV services throughout Lesotho. The revisions were driven by the Ministry of Health's desire to improve access to additional HIV prevention interventions such as event-driven PrEP and the dapivirine vaginal ring; complete optimisation of antiretroviral therapy; provide comprehensive guidance on implementation of key service delivery models; improve the management of advanced HIV disease; and align with recommendations related to tuberculosis, vertical transmission and HIV testing services.