This guide describes the purpose of pre-exposure prophylaxis (PrEP), the target audience for it, the steps for offering PrEP to individuals and the necessary screening process, as well as the responsibilities of health care providers and clients for ongoing monitoring. It is intended for all levels of the health system and community-based organisations. Additional sections provide details on how various actors will coordinate PrEP interventions and indicators for monitoring and evaluating PrEP use in the country.