Research on creating demand for voluntary medical male circumcision has generated insights that have helped improve uptake in some areas and sustain programmes in others where coverage had reached saturation level, according to AVAC’s annual report, No Prevention, No End. The report is a call to action and a guide for addressing the HIV prevention crisis that threatens progress in curtailing HIV epidemics worldwide. Graphics (including an infographic depicting how human-centred design could be used to increase uptake of VMMC) and sections of the report can be downloaded from the AVAC website.