The World Health Organization and UNAIDS provide practical guidance to help operationalise the scale-up of voluntary medical male circumcision services in both the public and private sectors. This guide outlines the process and explains the key elements required for effective scale-up: leadership and partnership, situation analysis, advocacy, enabling the policy and regulatory environment, strategic and operational planning, quality assurance and improvement, human resource development, commodity security, social change communication, and monitoring and evaluation. Countries must consider how best to sequence the key programme elements. This operational guide is included in the PEPFAR guide to best practices for VMMC site operations.