Developed to assist programme implementers with the waste management challenges associated with VMMC programmes, this toolkit contains guidance on the development of a waste management system to support VMMC services, standard operating procedures on waste disposal, and training tools for waste handlers and transporters. Based on South African National Standards, International Best Practice, and the SCMS Health Care Waste Management Model, this comprehensive set of tools provides guidance on building HCWM operational infrastructure, improves staff capacity, and aids stakeholders in managing the waste generated by VMMC campaigns. It is included in the PEPFAR guide to best practices for VMMC site operations.