The Conference on Retroviruses and Opportunistic Infections (CROI) was established in 1993 to provide a forum for basic scientists and clinical investigators to present, discuss and critique their investigations into the epidemiology and biology of human retroviruses and associated diseases. The synergy of basic science and clinical investigation has been a major contributor to the success of the meeting. Attendance at the conference is open to researchers and clinical educators actively involved in the study and management of HIV, other retroviruses, and related medical conditions. Limited space is also available to members of the media whose work aligns with the scientific and educational aims of the conference.