This issue of the newsletter reports on the 4th meeting of the community of practice in June 2022. The topic was scaling up effective programmes with young key populations. The sessions provided a deeper understanding of the need to prioritise young key populations in the HIV prevention response. The speakers focused on the global evidence and guidance on working with young key populations, discussed implementation considerations from the national programme and reinforced the need for involvement of young key populations in the design and implementation of programmes to enhance effectiveness.