The Consolidated guidelines on HIV, viral hepatitis and STI prevention, diagnosis, treatment and care for key populations July 2022 outline a public health response to HIV, viral hepatitis and sexually transmitted infections (STIs) for five key populations (men who have sex with men, sex workers, people in prisons and other closed settings, people who inject drugs and trans and gender diverse people). The guidelines present and discuss new recommendations and consolidate a range of recommendations and guidance from current WHO guidelines which are summarised here in this policy brief.