The 2025 national HIV prevention for the Kingdom of Eswatini provides a strategic refocus on its multisectoral and decentralized HIV prevention response, bringing prioritized interventions to scale and significantly improving availability, accessibility, acceptability, utilization and quality of comprehensive HIV prevention services. The Road Map seeks to inspire and shape HIV prevention policies and legislation, influence service delivery practices, improve the efficiency and effectiveness of coordination and accountability mechanisms and strengthening sector-based HIV prevention programmes.