This presentation provides an overview of the 2017-2021 Framework for Voluntary Medical Male Circumcision (VMMC 2021), including its alignment with the 2012-2016 Global Health Sector Strategy on HIV, its guiding principles, and its four strategic directions: 1) focused action for scale-up; 2) policies and services for impact; 3) innovations for acceleration and future; and 4) accountability for results and quality. Julia Samuelson of the World Health Organization’s Office of HIV/AIDS gave the presentation at the Meeting on Implementing the 2017-2021 Framework for VMMC for the Eastern and Southern Africa Region in Durban, South Africa, on 27 February 2017.