In December 2017, the 41st UNAIDS Programme Coordinating Board highlighted the urgent need for increased and collective efforts to address the HIV-related stigma, discrimination and criminalisation that were limiting access to essential services, increasing vulnerability to HIV and fueling the AIDS epidemic. In response to the call of the board’s delegation of nongovernmental organization representatives, the Global Partnership for Action to Eliminate All Forms of HIV-related Stigma and Discrimination was launched in 2018, on International Human Rights Day. This resource describes the partnership, reports on its initiatives and provides examples of efforts to reduce stigma and discrimination in a dozen countries.