The HIV Prevention 2025 Road Map offers guidance to all stakeholders who are seeking to reduce new HIV infections. All countries––whether or not they participated in the Global HIV Prevention Coalition in the past––have to intensify their HIV prevention efforts to end the AIDS epidemic. In 2020, the 28 focus countries of the Coalition together accounted for almost three-quarters of annual new HIV infections globally in 2020. Exceptional international and national efforts are needed in those countries and a growing list of focus countries,