The Global Men and HIV Technical Working Group’s (MENHT's) second webinar about men and pre-exposure prophylaxis (PrEP) included a session to clarify understanding of the updated World Health Organization guidelines on PrEP. It also featured presentations on the feasibility of a community-based delivery model among bar patrons in rural South Africa; reaching men with pharmacy-based PrEP delivery in Kenya; and insights on men and PrEP and post-exposure prophylaxis (PEP) from the SEARCH study in rural East Africa.