The Global HIV Prevention Coalition (GPC) convened a Ministerial Meeting on ‘HIV Prevention 2021-2025, taking stock, planning the future’ to review progress in implementing the HIV Prevention 2020 Road Map and pave the way to expand and amplify HIV prevention efforts through 2025. About 300 participants, including the Vice-President of Zimbabwe, 12 ministers of health from GPC countries and the heads of UNAIDS, UNFPA and the Global Fund, attended the virtual event. This report describes the meeting.