The second edition of this resource for site-level staff of implementing partners supported by the President’s Emergency Plan for AIDS Relief (PEPFAR) offers guidance on proven approaches to providing high-quality voluntary medical male circumcision (VMMC) services at the facility or site level. Edition 1 covered all aspects of the planning, launch, and oversight of daily operations at VMMC sites. Given the maturation of VMMC programs since 2012, the second edition focuses on optimising management of existing service locations, but also includes chapters for those establishing new sites. The ten chapters of the guide are available as stand-alone resources.