The purpose of this Guide is to: 1) Define a package of interventions that can be implemented by member states of the South African Development Community (SADC) to ensure that 90% of adolescent girls and young women (AGYW) and their male partners at risk of HIV infection have access to comprehensive combination HIV prevention services. 2) Provide a methodology for member states to define targets aligned with those defined in the 2016 Political Declaration and to measure the extent to which HIV prevention programmes are meeting the needs of AGYW and their male partners and reducing new HIV infections.