Clinical trials of two devices for performing voluntary medical male circumcision (VMMC) on adults and adolescents showed that PrePex and the ShangRing were safe and acceptable, but questions remained about their use in routine service delivery. This collection of 17 articles, published in the Journal of Acquired Immune Deficiency Syndromes, examines subsequent research on the introduction of the two devices, which have been prequalified by the World Health Organization. Studies from eight countries address important issues such as safety, acceptability, training, and the cost of using these devices to perform VMMC for HIV prevention.

• VMMC Devices—Introducing a New Innovation to a Public Health Intervention
• Innovative Methods of Male Circumcision for HIV Prevention—Getting the Right Evidence
• Surgical Outcomes of Newly Trained ShangRing Circumcision Providers
• Men's Understanding of and Experiences During the Postcircumcision Abstinence Period: Results from a Field Study of ShangRing Circumcision During Routine Clinical Services in Kenya and Zambia
• Factors Associated With Delayed Healing in a Study of the PrePex Device for Adult Male Circumcision in Kenya
• Randomized Controlled Trial of the ShangRing for Adult Medical Male Circumcision: Safety, Effectiveness, and Acceptability of Using 7 Versus 14 Device Sizes
• Safety Profile of PrePex Male Circumcision Device and Client Satisfaction with Adolescent Males Aged 13–17 Years in Zimbabwe
• Safety and Efficacy of the PrePex Male Circumcision Device: Results from Pilot Implementation Studies in Mozambique, South Africa, and Zambia
• Safety, Feasibility, and Acceptability of the PrePex Device for Adult Male Circumcision in Malawi
• Acceptability and Satisfaction Associated with the Introduction of the PrePex Circumcision Device in Maputo, Mozambique
• Safety and Acceptability of the PrePex Device When Used in Routine Male Circumcision Service Delivery during Active Surveillance in Zimbabwe
• Delivering PrePex Medical Male Circumcision Services through a Mobile Clinic: The Experience from a Pilot Project in North West Province, South Africa
• Participant Experiences and Views of Odor and PrePex Device Removal Pain in a VMMC Pilot Study in Botswana
• Perceptions of the PrePex Device Among Men Who Received or Refused PrePex Circumcision and People Accompanying Them
• Employing Demand-Based Volumetric Forecasting to Identify Potential for and Roles of Devices in Scale-Up of Medical Male Circumcision in Zambia and Zimbabwe
• Evaluating Opportunities for Achieving Cost Efficiencies through the Introduction of PrePex Device Male Circumcision in Adult VMMC Programs in Zambia and Zimbabwe
• Comparative Cost Analysis of Surgical and PrePex Device Male Circumcision in Zimbabwe and Mozambique