This tool contains practical advice on implementing HIV and sexually transmitted infection (STI) programmes with transgender people. Topics covered include community empowerment and human rights, addressing violence, stigma and discrimination, and delivering trans-competent services, especially for HIV and STI prevention, diagnosis, treatment and care. The tool also covers community-led outreach, safe spaces, and the use of information and communications technology in programming, and it offers strategies for managing programmes and building the capacity of trans-led organizations. It contains examples of good practices from around the world that can be used to support efforts to plan programmes and services with trans people.