Access to pre-exposure prophylaxis (PrEP) is still highly concentrated in a small number of countries; even in countries with widespread PrEP access, inequalities have emerged. The Global Men and HIV Technical Working Group’s (MENHT's) first webinar devoted to men and PrEP included a presentation on the World Health Organization’s updated guidelines on PrEP and reports on efforts to improve men’s access to and effective use of PrEP in Guatemala, the Philippines, South Africa and Zambia.